Toxicological consequences of cadmium oxide exposure in the rat lung
Thesis/Dissertation
·
OSTI ID:5216217
A system for the inhalation exposure of rats to CdO aerosols has been developed in order to study CdO-induced lung pathology in an experimental animal model. A correlative approach was taken in evaluating the morphological, biochemical and functional responses following exposure to two different doses of CdO aerosols. Acute exposure to CdO aerosols results in damage to pulmonary epithelium followed by epithelial hyperplasia and inflammatory cell influx. Lung injury produced by the low dose exposure (0.5 mg/m/sup 3/ x 180 min) was found to be reversible, while injury produced by the high dose exposure (5.0 mg/m/sup 3/ x 180 min) resulted in the development of peribronchiolar fibrosis. Biochemical responses of CdO exposure included dose-dependent increases in glutathione-related enzymes; i.e. glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD). When enzymatic activities were normalized for numbers of lung cells (as determined by lung DNA content), part of the enhancement of enzymatic activities could be attributed to increased total numbers of cells in the lung.
- Research Organization:
- Johns Hopkins Univ., Baltimore, MD (USA)
- OSTI ID:
- 5216217
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
AEROSOLS
ANIMALS
BIOLOGICAL MODELS
BODY
CADMIUM COMPOUNDS
CADMIUM OXIDES
CARBOXYLIC ACIDS
CHALCOGENIDES
COLLOIDS
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENZYME ACTIVITY
ENZYMES
GLUTATHIONE
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INHALATION
INTAKE
LUNGS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PEPTIDES
PEROXIDASES
POLYPEPTIDES
PORPHYRINS
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RESPIRATORY SYSTEM
RODENTS
SOLS
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
AEROSOLS
ANIMALS
BIOLOGICAL MODELS
BODY
CADMIUM COMPOUNDS
CADMIUM OXIDES
CARBOXYLIC ACIDS
CHALCOGENIDES
COLLOIDS
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENZYME ACTIVITY
ENZYMES
GLUTATHIONE
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INHALATION
INTAKE
LUNGS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PEPTIDES
PEROXIDASES
POLYPEPTIDES
PORPHYRINS
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RESPIRATORY SYSTEM
RODENTS
SOLS
TOXICITY
VERTEBRATES