Regeneration of hemopoietic and lymphoid tissues following total-body irradiation and therapeutic administration of thiamin diphosphate. [Mice, gamma radiation]

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:5205427

Vavrova, J; Nouza, K; Petjrek, P

Analysis was made of the mechanism of therapeutic application of thiamine diphosphate (TDP) in radiation sickness in mice. This agent increased the number of endogenous colonies in the spleen and incorporation of /sup 59/Fe in spleen and bone marrow with sublethal doses of radiation (500 and 600 R) and has no effect with a lethal dose (750 R). After administration of TDP to mice exposed to 500 R radiation, there is faster DNA synthesis in the spleen, thymus and bone marrow, as well as reliable increase in number of nuclear cells in femoral marrow.

• Research Organization: Inst. of Experimental Medicine, Prague
• OSTI ID: 5205427
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:3; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZINES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BIOSYNTHESIS
BODY
BONE MARROW
CFU
DAYS LIVING RADIOISOTOPES
DNA
ELECTROMAGNETIC RADIATION
EVEN-ODD NUCLEI
EXTERNAL IRRADIATION
GAMMA RADIATION
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRON 59
IRON ISOTOPES
IRRADIATION
ISOTOPES
LYMPHATIC SYSTEM
MAMMALS
MICE
NUCLEI
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PYRIMIDINES
RADIATION EFFECTS
RADIATION SYNDROME
RADIATIONS
RADIOISOTOPES
RECOVERY
RODENTS
SPLEEN
SYNTHESIS
THERAPY
THIAMINE
THIAZOLES
THYMUS
TISSUES
VERTEBRATES
VITAMIN B GROUP
VITAMINS
WHOLE-BODY IRRADIATION