Effects of single and repeated cigarette smoke-exposures on the activities of aryl hydrocarbon hydroxylase, epoxide hydratase and UDP glucuronosyltransferase in rat lung, kidney and small intestinal mucosa
Journal Article
·
· Res. Commun. Chem. Pathol. Pharmacol.; (United States)
OSTI ID:5204203
A single exposure to cigarette smoke for one hour decreased the pulmonary microsomal epoxide hydratase activity in rats. A more rapid decrease was seen after 5 consecutive exposures, one hour daily. Meanwhile, the activity of pulmonary aryl hydrocarbon hydroxylase (AHH) increased several fold. In small intestinal mucosa the activities of AHH and epoxide hydratase were enhanced both by single and repeated cigarette smoke-exposures. In kidney the activity of AHH increased, whereas neither that of epoxide hydratase nor of UDP glucuronosyl-transferase changed. In small intestinal mucosa the activity of UDP glucuronosyltransferase increased after repeated smoke-exposures, but in lung no clear change in the UDP glucuronosyltransferase activity was detected.
- Research Organization:
- Univ. of Turku, Finland
- OSTI ID:
- 5204203
- Journal Information:
- Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 17:1; ISSN RCOCB
- Country of Publication:
- United States
- Language:
- English
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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BODY
CATALYSIS
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
ENZYME INHIBITORS
ENZYMES
GASTROINTESTINAL TRACT
HYDROXYLASE
INTESTINES
KIDNEYS
LUNGS
MAMMALS
METABOLISM
ORGANS
OXIDOREDUCTASES
RATS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
TOBACCO SMOKES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BODY
CATALYSIS
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
ENZYME INHIBITORS
ENZYMES
GASTROINTESTINAL TRACT
HYDROXYLASE
INTESTINES
KIDNEYS
LUNGS
MAMMALS
METABOLISM
ORGANS
OXIDOREDUCTASES
RATS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
TOBACCO SMOKES
VERTEBRATES