Organ specificity of aryl hydrocarbon hydroxylase induction by cigarette smoke

Journal Article · Fri Jun 01 04:00:00 EDT 1990 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01702187· OSTI ID:5457946

Yoshikawa, M; Arashidani, K; Kawamoto, T; Kodama, Y ^[1]

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1. Univ. of Occupational and Environmental Health, Fukuoka (Japan)

Biotransformation of many chemicals found in cigarette smoke, such as PAHs and nitrosamines, is generally considered essential for the mutagenic, carcinogenic effects of these xenobiotics. In fact, the genotic action of these premutagens or precarcinogens is dependent on metabolic activation catalyzed by microsomal monooxygenases. The first enzymatic reaction of the PAHs metabolic pathway is catalyzed by a cytochrome P-450-dependent monooxygenase, the aryl hydrocarbon hydroxylase (AHH). AHH leads to the formation of reactive arene oxides, which are further metabolized by enzymatic and non-enzymatic reaction into many metabolites. AHH induction in laboratory animals exposed to cigarette smoke has also been reported, and the data show that this response is highly dependent on species and tissues. Exposure of small laboratory animals to cigarette smoke generally induces AHH in the kidney and lung, while the effect of cigarette smoke on the hepatic AHH activity appears variable.

• OSTI ID: 5457946
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Journal Name: Bulletin of Environmental Contamination and Toxicology; (United States) Vol. 44:6; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
ARYL 4-MONOOXYGENASE
BODY
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
ENZYME ACTIVITY
ENZYME INDUCTION
ENZYMES
GENE REGULATION
GLANDS
HYDROXYLASES
INHALATION
INTAKE
KIDNEYS
LIVER
LUNGS
MAMMALS
METABOLIC ACTIVATION
ORGANS
OXIDOREDUCTASES
RATS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
TOBACCO SMOKES
VERTEBRATES