R46 and pKM101 plasmid-mediated resistance to ionizing radiation in Escherichia coli

Journal Article · Sun Sep 01 00:00:00 EDT 1985 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576763· OSTI ID:5198231

Francia, I; Hernadi, S; Szabolcs, M; Hernadi, F

The ability of the R46 R factor and its derivative pKM101 to modify sensitivity to /sup 60/Co ..gamma.. radiation was studied. In Escherichia coli K12 both plasmids enhanced bacterial survival after /sup 60/Co ..gamma.. irradiation. This effect was dependent on recA/sup +/ genotype but not on recB/sup +/, recB/sup +/recC/sup +/, and recF/sup +/ genotypes. 5-Fluorouracil eliminated the R46 R factor from the parent and its rec/sup -/ mutant strains. These strains lost not only the antibiotic resistance coded for R46 R factor but their radioresistance as well.

• Research Organization: Univ. Medical School, Debrecen, Hungary
• OSTI ID: 5198231
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 103:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIMETABOLITES
AZINES
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CELL CONSTITUENTS
CELL KILLING
COBALT 60
COBALT ISOTOPES
DATA
DRUGS
ELECTROMAGNETIC RADIATION
ESCHERICHIA COLI
EXPERIMENTAL DATA
FLUOROURACILS
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
MUTANTS
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PLASMIDS
PYRIMIDINES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
SURVIVAL CURVES
URACILS
YEARS LIVING RADIOISOTOPES