Effects of maternal thrombocytopenia on platelet counts of pre- and postnatal mice
The effects of maternal thrombocytopenia on platelet counts of pre- and postnatal mice were determined. Platelet counts of gravid mice were reduced at 2 to 3 days before parturition by injection of rabbit anti-mouse platelet serum (RAMPS). Marked rebound-thrombocytosis was observed after 4 to 6 days. Platelet counts of pre- and postnatal mice whose mothers were injected with RAMPS 3 days before parturition were unaltered except at 1 day before and at the time of birth when they were significantly (P less than 0.005) reduced. The results of immunodiffusion techniques showed that RAMPS crossed the placental barrier resulting in reduced platelet counts of the fetuses, but significant fetal rebound-thrombocytosis was not observed.
- Research Organization:
- Univ. of Tennessee Memorial Research Center, Knoxville
- OSTI ID:
- 5191972
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 21:8; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BLOOD PLATELETS
BODY FLUIDS
DISEASES
FETAL MEMBRANES
FETUSES
HEMIC DISEASES
HEMORRHAGE
MAMMALS
MEMBRANES
MICE
PARTURITION
PATHOLOGICAL CHANGES
PLACENTA
PREGNANCY
RODENTS
SYMPTOMS
THROMBOPOIESIS
VERTEBRATES