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Modulation of radiation-induced hemopoietic suppression by acute thrombocytopenia

Journal Article · · Ann. N.Y. Acad. Sci.; (United States)
; ; ;
Modifications of radiation-induced hemopoietic suppression by acute thrombocytopenia were evaluated. Immediately before or after exposure to sublethal irradiation, mice were given a single injection of anti-mouse platelet serum (APS), normal heterologous serum, neuraminidase (N'ase), or saline, or no further treatment was provided. Hemopoiesis was evaluated by blood cell counts, hematocrits, and incorporation of (75Se)selenomethionine into platelets. APS and N'ase induced an acute thrombocytopenia from which there was partial recovery before the platelet count started to fall from the radiation. During the second post-treatment week, both thrombocytopoiesis and erythropoiesis were greater in mice that received APS or N'ase in addition to radiation than in control irradiated mice. Differences in leukopoiesis were not apparent. Therefore, both thrombocytopoiesis and erythropoiesis appeared to be responsive to a stimulus generated by acute thrombocytopenia in sublethally irradiated mice.
Research Organization:
Univ. of California, Berkeley
OSTI ID:
5737707
Journal Information:
Ann. N.Y. Acad. Sci.; (United States), Journal Name: Ann. N.Y. Acad. Sci.; (United States); ISSN ANYAA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BLOOD FORMATION
BLOOD PLATELETS
BODY
BODY FLUIDS
ERYTHROPOIESIS
HEMATOPOIETIC SYSTEM
IMMUNE SERUMS
IRRADIATION
MAMMALS
MATERIALS
MICE
RADIATION EFFECTS
RADIOINDUCTION
RECOVERY
RODENTS
STIMULATION
SUBLETHAL IRRADIATION
VERTEBRATES