Generation and characterization of antigenic variants induced by exposure of tumor cells to UV radiation in vitro
Thesis/Dissertation
·
OSTI ID:5184107
Antigenic changes present in nonantigenic tumor cells exposed to UV radiation (UV) in vitro were investigated by addressing the following questions: (1) Are antigenic variants (AV) produced that are rejected in normal but not immunosuppressed mice (2) Does generation of AV depend upon intrinsic properties of the cells exposed or result from the action of UV (3) Is antigenic modification induced by UV due to increased histocompatibility antigen expression (4) Do AV crossreact immunologically with parental tumor or with other AV and (5) Is the UV-associated common antigen expressed on UV-induced tumors present on UV-irradiated tumor cells AV were generated at different frequencies following in vitro UV irradiation of a spontaneous murine fibrosarcoma, a murine melanoma, and two melanoma clones. Immunological experiments demonstrated that the AV and parental cells shared a determinant that was susceptible to immune recognition, but incapable of inducing immunity. In contrast, the AV were noncrossreactive, suggesting that variant-specific antigens were also expressed. Finally, the AV were recognized by UV-induced suppressor cells, indicating that the UV-associated common antigen expressed by UV-induced tumors was also present.
- Research Organization:
- Texas Univ., Houston, TX (USA). Health Science Center
- OSTI ID:
- 5184107
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMICAL COMPOSITION
DISEASES
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IMMUNE REACTIONS
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Cells
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMICAL COMPOSITION
DISEASES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
IMMUNE REACTIONS
IN VITRO
MAMMALS
MELANOMAS
MICE
NEOPLASMS
RADIATION EFFECTS
RADIATIONS
RODENTS
SARCOMAS
TUMOR CELLS
ULTRAVIOLET RADIATION
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