Early corticosteroid administration in experimental radiation-induced heart disease

Journal Article · Fri Feb 01 04:00:00 EST 1980 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.134.2.7352245· OSTI ID:5179203

Reeves, W C; Stryker, J A; Abt, A A; Chung, C K; Whitesell, L; Zelis, R

The ability of dexamethasone (DEX) to reduce the severity of the late stage of radiation-induced heart disease (RIHD) was assessed in 25 New Zealand white rabbits. Ten rabbits served as unirradiated controls (CONT). In Group A, seven rabbits received intravenous DEX prior to irradiation and every 24 hours for three consecutive days. DEX was not administered to the eight rabbits in Group B. At 100 days postirradiation, the severity of the late state was determined by microscopic examination (MICRO) for myocardial fibrosis and determination of myocardial hydroxyproline content (MHP). Myocardial fibrosis was evident in groups A (40%) and B (80%) while none was present in CONT by MICRO. One rabbit in Group B with no fibrosis by MICRO had abnormally increased MHP. MHP was significantly increased in Groups A and B, as compared to CONT (p < 0.01). In addition to less fibrosis by MICRO, Group A demonstrated a significant reduction of MHP when compared to Group B (p < 0.05). Determination of MHP may be superior to MICRO in the detection of the late stage of RIHD. Also, early DEX administration appears to reduce myocardial collagen content (fibrosis) in this experimental model.

• Research Organization: Pennsylvania State Univ., Hershey
• OSTI ID: 5179203
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 134:2; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AMINES
AMINO ACIDS
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORTICOSTEROIDS
DATA
DATA FORMS
DEXAMETHASONE
DISEASES
ELECTRONS
ELEMENTARY PARTICLES
ENERGY RANGE
EXPERIMENTAL DATA
FERMIONS
FIBROSIS
GLUCOCORTICOIDS
HEART
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY ACIDS
HYDROXY COMPOUNDS
HYDROXYPROLINE
INFORMATION
KETONES
LEPTONS
MAMMALS
MEV RANGE
MEV RANGE 10-100
MICROSCOPY
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PREGNANES
PYRROLES
PYRROLIDINES
RABBITS
RADIATION EFFECTS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
STEROID HORMONES
STEROIDS
TABLES
THERAPY
VERTEBRATES