Myocardial hydroxyproline reduced by early administration of methylprednisolone or ibuprofen to rabbits with radiation-induced heart disease

Journal Article · Sat May 01 04:00:00 EDT 1982 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.65.5.924· OSTI ID:6815925

Reeves, W C; Cunningham, D; Schwiter, E J; Abt, A; Skarlatos, S; Wood, M A; Whitesell, L

The ability of methylprednisolone (MP) and ibuprofen (IB) to reduce the severity of the late state of radiation-induced heart disease was assessed in 57 New Zealand white rabbits. Before and shortly after cardiac irradiation, 15 rabbits received i.v. MP, 30 mg/kg twice daily for 3 days, and 15 others received IB, 12.5 mg/kg twice daily for 2 days. No drug was administered to 14 irradiated rabbits, and neither irradiation nor drugs were administered to 13 rabbits that served as controls, All 15 rabbits treated with MP and 13 of the 15 treated with IB lived for 100 days. Only seven of the untreated, irradiated rabbits lived that long. Longevity of each treated group of rabbits was better (p less than 0.01 and 0.05) than that of the untreated, irradiated rabbits. Surviving rabbits were killed 100 days after irradiation. Pericarditis (p less than 0.05) and pericardial effusion (p less than 0.01) were less frequent in the treated, irradiated groups than in the untreated, irradiated rabbits. At least some rabbits in each irradiated group had microscopic evidence of myocardial fibrosis. The fibrosis was quantitated by determination of myocardial hydroxyproline concentrations (MHP). MHP concentration in the untreated, irradiated rabbits was greater than in those treated with MP (p less than 0.05) or IB (p less than 0.01) and in the untreated, unirradiated rabbits (p less than 0.01). Early administration of MP or IB retarded the development of myocardial fibrosis, pericarditis and pericardial effusion, and improved survival in this experimental model of radiation-induced heart disease.

• Research Organization: Division of Cardiology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey
• OSTI ID: 6815925
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 65:5; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AMINES
AMINO ACIDS
ANIMALS
AZOLES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
CORTICOSTEROIDS
DRUGS
FIBROSIS
GLUCOCORTICOIDS
HEART
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY ACIDS
HYDROXY COMPOUNDS
HYDROXYPROLINE
IRRADIATION
KETONES
KINETICS
LOCAL IRRADIATION
MAMMALS
MUSCLES
MYOCARDIUM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PREDNISOLONE
PREGNANES
PYRROLES
PYRROLIDINES
QUANTITATIVE CHEMICAL ANALYSIS
QUANTITY RATIO
RABBITS
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
STEROID HORMONES
STEROIDS
VERTEBRATES