Survival and kinetics of Chinese hamster ovary cell subpopulations induced by Adriamycin and radiation

Conference · Wed Aug 01 04:00:00 EDT 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5176800

Schneiderman, M H

Mitotic selection of Chinese hamster ovary (CHO) cells, at 10 min intervals after the initiation of Adriamycin and/or x-ray treatment was used to measure the kinetics and survival of cells which progressed without delay, the ''refractory'' cells, the cells that reached mitosis only after recovery from the treatment-induced delay, the ''recovered'' cells, and the survival of the cells remaining attached to the flask 5 h after treatment. The cell kinetics were determined from the rate at which cells entered mitosis, and the reproductive integrity from the survival of the selected refractory, recovered and remaining (unselected) cells.

• Research Organization: Thomas Jefferson Univ., Philadelphia, PA
• OSTI ID: 5176800
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 5:8
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBIOTICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CULTURES
CELL CYCLE
CELL DIVISION
CELL KILLING
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOXORUBICIN
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FEMALE GENITALS
GONADS
HAMSTERS
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
MAMMALS
MITOSIS
MITOTIC DELAY
MITOTIC INDEX
NUMERICAL DATA
ORGANS
OVARIES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL CURVES
SYNCHRONOUS CULTURES
TOXICITY
VERTEBRATES
X RADIATION