Comparative evaluation of genetic toxicity patterns of carcinogens and noncarcinogens: strategies for predictive use of short-term assays

Journal Article · Sun Nov 01 00:00:00 EST 1987 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.877587· OSTI ID:5164608

Tennant, R W; Spalding, J W; Stasiewicz, S; Caspary, W D; Mason, J M; Resnick, M A

The results of a recent comprehensive evaluation of the relationship between four measures of in vitro genetic toxicity and the capacity of the chemicals to induce neoplasia in rodents carry some important implications. The results showed that while the Salmonella mutagenesis assay detected only about half of the carcinogenes as mutagens, the other three in vitro assays (mutagenesis in MOLY cells or induction of aberrations or SCEs in CHO cells) did not complement Salmonella since they failed to effectively discriminate between the carcinogens and noncarcinogens found negative in the Salmonella assay. The specificity of the Salmonella assay for this group of 73 chemicals was relatively high (only 4 of 29 noncarcinogens were positive). Therefore, the authors have begun to evaluate in vivo genetic toxicity assays for their ability to complement Salmonella in the identification of carcinogens.

• Research Organization: National Institute of Environmental Health Sciences, Research Triangle Park, NC (USA)
• OSTI ID: 5164608
• Journal Information: Environ. Health Perspect.; (United States), Vol. 75
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CARCINOGENESIS
GENETICS
CARCINOGENS
BIOASSAY
TOXICITY
MUTAGENS
BENZENE
BONE MARROW CELLS
CHO CELLS
CHROMOSOMAL ABERRATIONS
DNA REPLICATION
DROSOPHILA
IN VITRO
IN VIVO
LABELLED COMPOUNDS
MUTAGEN SCREENING
MUTAGENESIS
ONCOGENIC TRANSFORMATIONS
PHOSPHORUS 32
SALMONELLA TYPHIMURIUM
SISTER CHROMATID EXCHANGES
ANIMAL CELLS
ANIMALS
AROMATICS
ARTHROPODS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGY
CELL TRANSFORMATIONS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DIPTERA
FLIES
FRUIT FLIES
HYDROCARBONS
INSECTS
INVERTEBRATES
ISOTOPES
LIGHT NUCLEI
MICROORGANISMS
MUTATIONS
NUCLEI
NUCLEIC ACID REPLICATION
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PATHOGENESIS
PHOSPHORUS ISOTOPES
RADIOISOTOPES
SALMONELLA
SCREENING
SOMATIC CELLS
560300* - Chemicals Metabolism & Toxicology
550401 - Genetics- Tracer Techniques