Comparative evaluation of genetic toxicity patterns of carcinogens and noncarcinogens: strategies for predictive use of short-term assays

Journal Article · Sun Nov 01 04:00:00 EST 1987 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.877587· OSTI ID:5164608

Tennant, R W; Spalding, J W; Stasiewicz, S; Caspary, W D; Mason, J M; Resnick, M A

The results of a recent comprehensive evaluation of the relationship between four measures of in vitro genetic toxicity and the capacity of the chemicals to induce neoplasia in rodents carry some important implications. The results showed that while the Salmonella mutagenesis assay detected only about half of the carcinogenes as mutagens, the other three in vitro assays (mutagenesis in MOLY cells or induction of aberrations or SCEs in CHO cells) did not complement Salmonella since they failed to effectively discriminate between the carcinogens and noncarcinogens found negative in the Salmonella assay. The specificity of the Salmonella assay for this group of 73 chemicals was relatively high (only 4 of 29 noncarcinogens were positive). Therefore, the authors have begun to evaluate in vivo genetic toxicity assays for their ability to complement Salmonella in the identification of carcinogens.

• Research Organization: National Institute of Environmental Health Sciences, Research Triangle Park, NC (USA)
• OSTI ID: 5164608
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 75; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

550401 -- Genetics-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
ARTHROPODS
BACTERIA
BENZENE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOASSAY
BIOLOGY
BONE MARROW CELLS
CARCINOGENESIS
CARCINOGENS
CELL TRANSFORMATIONS
CHO CELLS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DIPTERA
DNA REPLICATION
DROSOPHILA
FLIES
FRUIT FLIES
GENETICS
HYDROCARBONS
IN VITRO
IN VIVO
INSECTS
INVERTEBRATES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
MUTAGENS
MUTATIONS
NUCLEI
NUCLEIC ACID REPLICATION
ODD-ODD NUCLEI
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
PATHOGENESIS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIOISOTOPES
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
TOXICITY