Genotoxicology of N-nitroso compounds
Book
·
OSTI ID:6499806
This book attempts to demonstrate the complexity of the mechanisms of biological action of the toxic N-nitroso compounds. The conclusions presented on genetic toxicology are based on comparative studies of biological assays and a firm foundation of chemical structural relations among N-nitroso compounds. Topics considered include the formation of N-nitroso compounds and their significance, N-nitrosamine mutagenicity using the Salmonella/Mammalian-Microsome Mutagenicity Assay, the structural basis for the mutagenic activity of N-nitrosamines in the Salmonella Histidine Reversion Assay, the effect of pH and structure on the mutagenic activity of N-nitroso compounds, the induction of bacteriophage lambda by N-nitroso compounds, the relationship between the carcinogenicity and mutagenicity of nitrosamines in a Hepatocyte-Mediated Mutagenicity Assay, the mutagenic activity of nitrosamines in mammalian cells (study with the CHO/HGPRT and human leukocyte SCE assays), dimethylnitrosamine demethylase and the mutagenicity of dimethylnitrosamine (effects of rodent liver fractions and dimethylsulfoxide), the relationship between metabolism and mutagenicity of two cyclic nitrosamines, structureactivity relations in carcinogenesis by N-nitroso compounds, and a comparison of mutagenic and carcinogenic properties.
- OSTI ID:
- 6499806
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AZOLES
BACTERIA
BACTERIOPHAGES
BIOASSAY
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CARCINOGENESIS
CELL CONSTITUENTS
CHROMOSOMAL ABERRATIONS
COMPARATIVE EVALUATIONS
ENZYMES
GENETIC EFFECTS
GLYCOSYL TRANSFERASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HISTIDINE
HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE
IMIDAZOLES
LIVER CELLS
MAMMALS
METABOLISM
MICROORGANISMS
MICROSOMES
MUTAGENESIS
MUTATIONS
NITROSAMINES
NITROSO COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
PARASITES
PATHOGENESIS
PENTOSYL TRANSFERASES
PH VALUE
SALMONELLA
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
TOXICITY
TRANSFERASES
VERTEBRATES
VIRUSES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AZOLES
BACTERIA
BACTERIOPHAGES
BIOASSAY
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CARCINOGENESIS
CELL CONSTITUENTS
CHROMOSOMAL ABERRATIONS
COMPARATIVE EVALUATIONS
ENZYMES
GENETIC EFFECTS
GLYCOSYL TRANSFERASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HISTIDINE
HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE
IMIDAZOLES
LIVER CELLS
MAMMALS
METABOLISM
MICROORGANISMS
MICROSOMES
MUTAGENESIS
MUTATIONS
NITROSAMINES
NITROSO COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
PARASITES
PATHOGENESIS
PENTOSYL TRANSFERASES
PH VALUE
SALMONELLA
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
TOXICITY
TRANSFERASES
VERTEBRATES
VIRUSES