Structure activity studies with n-nitrosamines using Salmonella typhimurium and escherichia coli

Conference · Thu Jan 01 04:00:00 EST 1981

OSTI ID:6288041

Rao, T K; Epler, J L; Lijinsky, W

Cyclic nitrosamines exhibited a relationship between their mutagenic activity and molecular ring size. They exhibited a closer relationship between their mutagenic and carcinogenic properties. Substitution with alkyl or hydroxy groups did not affect the biological activity. Substitution in the ..cap alpha..-positions to the N-nitroso group eliminated both mutagenic and carcinogenic properties. Halogen substitution enhanced carcinogenic activity and had slight if any effect on mutagenicity. Carboxy substitution eliminated the biological activity. Aliphatic nitrosamines failed to show any relationship between mutagenesis and carcinogenesis. Use of E. coli assay not only substantiated Salmonella results; it was also capable of identifying certain carcinogens (nitrosopyrroline, 3,4-dibromonitrosopyrrolidine and methylethylnitrosamine) as mutagens that were missed in the Salmonella assay.

• Research Organization: Oak Ridge National Lab., TN (USA); Frederick Cancer Research Center, MO (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6288041
• Report Number(s): CONF-810973-1; ON: DE81030808
• Country of Publication: United States
• Language: English

Related Subjects

560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
BACTERIA
BIOLOGICAL INDICATORS
CARCINOGENESIS
CORRELATIONS
ESCHERICHIA COLI
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING