Short-term test for predicting the potential of xenobiotics to impair reproductive success in fish

Journal Article · Sat Jun 01 04:00:00 EDT 1985 · Ecotoxicol. Environ. Saf.; (United States)

DOI:https://doi.org/10.1016/0147-6513(85)90046-6· OSTI ID:5147829

Landner, L; Neilson, A H; Soerensen, L T; Taernholm, A V; Viktor, T

Short-term screening tests with the zebra fish (Brachydanio rerio) have been developed for predicting the potential of xenobiotics to impair reproductive success in fish. The aim was to find simple and sensitive test parameters and to simulate exposure situations typical for anadromous fish species (salmonids), which generally cross heavily polluted coastal areas or estuaries before they reach uncontaminated upstream spawning areas. Therefore, particular attention was directed to tests designed to assess adverse effects induced during gametogenesis in adult fish. The test protocol involves exposure of adults prior to, but not during, spawning and the effects are measured in the offspring as alterations in hatching frequency and hatching rate of eggs, and survival and stress tolerance of embryos and larvae. Some representative examples of the application of these tests are given, and it is shown that impairment of reproductive success can be induced by exposure of parent fish prior to spawning at concentrations of xenobiotics at least five times lower than those yielding effects during direct exposure of embryos and larvae. It is suggested that, in hazard assessment programs, tests of the effect of xenobiotics on the offspring of preexposed adults be routinely incorporated.

• Research Organization: Swedish Environmental Research Institute, Stockholm
• OSTI ID: 5147829
• Journal Information: Ecotoxicol. Environ. Saf.; (United States), Journal Name: Ecotoxicol. Environ. Saf.; (United States) Vol. 3; ISSN EESAD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANADROMOUS FISHES
ANIMALS
AQUATIC ORGANISMS
DOSE-RESPONSE RELATIONSHIPS
EGGS
EMBRYOS
FERTILIZATION
FISHES
FORECASTING
GAMETOGENESIS
LARVAE
OVULATION
POLLUTION
REPRODUCTION
SALMON
SCREENING
SENSITIVITY
SIMULATION
TERATOGENS
VERTEBRATES
WATER POLLUTION
XENOBIOTICS