Specialized DNA polymerases in lymphoid cells
Conference
·
· Cold Spring Harbor Symp. Quant. Biol.; (United States)
OSTI ID:5146266
Terminal transferase remains the only good candidate for a somatic-mutation-producing DNA polymerase. It is clearly found that in immature, but not in mature, T cells. It is also found in a population of bone marrow cells that lack an inducible T-cell marker and that could be B-cell precursors (but might well be unrelated to B cells). The most suggestive observation that could be interpreted as evidence for terminal transferase in pre-B cells is the occurrence of activity in Abelson virus-induced tumor cells. The status of Abelson tumor cells is, however, uncertain.
- Research Organization:
- Massachusetts Inst. of Tech., Cambridge
- OSTI ID:
- 5146266
- Conference Information:
- Journal Name: Cold Spring Harbor Symp. Quant. Biol.; (United States) Journal Volume: 41
- Country of Publication:
- United States
- Language:
- English
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Activity of DNA-dependent DNA polymerase and aspartate--carbamoyl transferase after separation of rat marrow and spleen cells in an albumin density gradient under normal conditions, after irradiation and administration of DNA. [Gamma radiation]
Journal Article
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Fri Dec 31 23:00:00 EST 1976
· Radiobiology (USSR) (Engl. Transl.); (United States)
·
OSTI ID:5166723
Related Subjects
550200* -- Biochemistry
550300 -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CHEMISTRY
CONNECTIVE TISSUE CELLS
DNA
ENZYMES
IMMUNOLOGY
LEUKOCYTES
LYMPHOCYTES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POLYMERASES
SOMATIC CELLS
THYMOCYTES
TRANSFERASES
TUMOR CELLS
550300 -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CHEMISTRY
CONNECTIVE TISSUE CELLS
DNA
ENZYMES
IMMUNOLOGY
LEUKOCYTES
LYMPHOCYTES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
POLYMERASES
SOMATIC CELLS
THYMOCYTES
TRANSFERASES
TUMOR CELLS