Small differences in Drosophila tropomyosin expression have significant effects on muscle function
Journal Article
·
· Molecular and Cellular Biology; (United States)
- Univ. of Illinois, Chicago (United States)
- Georgetown Univ., Washington, DC (United States)
The effects of promoter deletions on Drosophila tropomyosin I (TmI) gene expression have been determined by measuring TmI RNA levels in transformed flies. Decreases in RNA levels have been correlated with rescue of flightless and jumpless mutant phenotypes in Ifm(3)3 mutant transformed flies and changes in muscle ultrastructure. The results of this analysis have allowed us to identify a region responsible for 20% of maximal TmI expression, estimate threshold levels of TmI RNA required for indirect flight and jump muscle function, and obtain evidence suggesting that sarcomere length may be an important determinant of flight muscle functions.
- OSTI ID:
- 5144545
- Journal Information:
- Molecular and Cellular Biology; (United States), Journal Name: Molecular and Cellular Biology; (United States) Vol. 11:12; ISSN MCEBD; ISSN 0270-7306
- Country of Publication:
- United States
- Language:
- English
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