Marf-mediated mitochondrial fusion is imperative for the development and functioning of indirect flight muscles (IFMs) in drosophila
Journal Article
·
· Experimental Cell Research
- Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, 560 012 (India)
- Department of Biochemistry, Indian Institute of Science, Bangalore, 560012 (India)
Highlights: • Mitochondrial fusion is essential during development of Drosophila IFM. • Marf expression is required during early muscle development. • Marf knock down during IFM development affects mitochondrial shape and function. • Marf deficiency alters myofibril size and decreases muscle function. Dynamic changes in mitochondrial shape and size are vital for mitochondrial health and for tissue development and function. Adult Drosophila indirect flight muscles contain densely packed mitochondria. We show here that mitochondrial fusion is critical during early muscle development (in pupa) and that silencing of the outer mitochondrial membrane fusion gene, Marf, in muscles results in smaller mitochondria that are functionally defective. This leads to abnormal muscle development resulting in muscle dysfunction in adult flies. However, post-developmental silencing of Marf has no obvious effects on mitochondrial and muscle phenotype in adult flies, indicating the importance of mitochondrial fusion during early muscle development.
- OSTI ID:
- 23195359
- Journal Information:
- Experimental Cell Research, Journal Name: Experimental Cell Research Journal Issue: 2 Vol. 399; ISSN 0014-4827; ISSN ECREAL
- Country of Publication:
- United States
- Language:
- English
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