Effectiveness of anticancer drugs determined in nude mice inoculated with (/sup 125/I)5-iodo-2'-deoxyuridine-prelabeled human melanoma cells

Journal Article · Mon Apr 01 00:00:00 EST 1985 · J. Natl. Cancer Inst.; (United States)

OSTI ID:5126399

Lockshin, A; Giovanella, B C; Vardeman, D M; Mendoza, J T; Quian, C; Kozielski, T; Stehlin, Jr, J S

Anticancer drugs were tested on NIH-2 nude mice inoculated ip with BRO human melanoma cells, which are rapidly lethal for these hosts. Criteria for drug activity were a) increased host survival and b) an increased rate of radioactivity loss from mice bearing BRO cells prelabeled with (/sup 125/I)5-iodo-2'-deoxyuridine. Diphtheria toxin, which is selectively toxic to human cells compared to mouse cells, prolonged host survival and accelerated /sup 125/I elimination in a dose-dependent manner. Drugs that increased the rate of /sup 125/I loss compared to the rate of untreated mice also prolonged the lives of treated mice. With one exception, drugs that did not accelerate /sup 125/I elimination had little or no effect on the length of survival.

• Research Organization: St. Joseph Hospital, Houston, TX
• OSTI ID: 5126399
• Journal Information: J. Natl. Cancer Inst.; (United States), Vol. 4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANTINEOPLASTIC DRUGS
EVALUATION
IODINE 125
EXCRETION
TRACER TECHNIQUES
IODODEOXYURIDINE
MAN
MICE
TUMOR CELLS
VINBLASTINE
ALKALOIDS
ANIMAL CELLS
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AROMATICS
AZAARENES
AZINES
AZOLES
BETA DECAY RADIOISOTOPES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
IODOURACILS
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRIMATES
PYRIMIDINES
PYRROLES
RADIOISOTOPES
RIBOSIDES
RODENTS
URACILS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics