Effects of propionate and methylmalonate on conversions of acetate, butyrate, and D(-)-3-hydroxybutyrate to fatty acids and carbon dioxide by mammary tissue slices of goats
Journal Article
·
· J. Dairy Sci.; (United States)
Incorporations of (1-carbon-14) acetate, (1-carbon-14) propionate, n-(1-carbon-14) butyrate, and D(-)-3-hydroxy(3-carbon-14) butyrate into individual milk fatty acids and their conversion to carbon dioxide were studied in vitro with caprine mammary tissue slices in the presence and absence of propionate and methylmalonate. Neither propionate nor methylmalonate affected incorporation of these substances into fatty acids. In a decreasing order butyrate, acetate, propionate, and D(-)-3-hydroxybutyrate were converted to carbon dioxide. Acetate had the highest incorporation rate into fatty acids followed by D(-)-3-hydroxybutyrate, butyrate, and propionate. Labeled propionate was incorporated mainly into odd-numbered fatty acids. Results do not support the theory that either propionate or its metabolite, methylmalonate, inhibit de novo synthesis of fatty acids in the mammary gland in relation to the etiology of low milk fat syndrome.
- Research Organization:
- Univ. of Alberta, Edmonton, Canada
- OSTI ID:
- 5125332
- Journal Information:
- J. Dairy Sci.; (United States), Journal Name: J. Dairy Sci.; (United States) Vol. 3; ISSN JDSCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACETATES
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BUTYRIC ACID
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHALCOGENIDES
CULTURE MEDIA
DICARBOXYLIC ACIDS
DOMESTIC ANIMALS
GOATS
LABELLED COMPOUNDS
LACTATION
MAMMALS
METABOLISM
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PREGNANCY
PROPIONIC ACID
RUMINANTS
SYNTHESIS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ACETATES
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BUTYRIC ACID
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHALCOGENIDES
CULTURE MEDIA
DICARBOXYLIC ACIDS
DOMESTIC ANIMALS
GOATS
LABELLED COMPOUNDS
LACTATION
MAMMALS
METABOLISM
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PREGNANCY
PROPIONIC ACID
RUMINANTS
SYNTHESIS
VERTEBRATES