Effects of three diets on mercury excretion after methylmercury administration

Journal Article · Mon Jan 01 04:00:00 EST 1979 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF02026922· OSTI ID:5125316

Landry, T D; Doherty, R A; Gates, A H

In contrast to adults, suckling mice excrete minimal amounts of their mercury body burdens until the approximate time of weaning to a solid diet, when there is an abrupt increase in mercury elimination. Increased gut absorption of inorganic Hg in rats fed a milk diet has been reported. These observations suggest that dietary components may influence absorption and excretion of Hg compounds. This possibility was examined by determining the effects of (1) an evaporated whole milk diet, (2) a chemically defined liquid diet, and (3) a pelleted rodent diet on Hg retention in mice after administration of an apparently non-toxic dose of methylmercury (MeHg). Whole body Hg elimination and fecal and urinary Hg excretion were measured daily for two weeks. Two weeks after MeHg administration, Hg concentrations in whole body, brain, liver, kidney and whole blood were determined. The diet groups showed differences in whole body Hg retention and fecal Hg excretion.

• Research Organization: Univ. of Rochester, NY
• OSTI ID: 5125316
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 22; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY BURDEN
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CLEARANCE
DIET
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
EXCRETION
FECES
GLANDS
INTESTINAL ABSORPTION
KIDNEYS
LIVER
MAMMALS
MATERIALS
MERCURY
METABOLISM
METALS
METHYLMERCURY
MICE
NEONATES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
RESPONSE MODIFYING FACTORS
RETENTION
RODENTS
TISSUE DISTRIBUTION
UPTAKE
URINE
VERTEBRATES
WASTES