Comparison of ouabain-sensitive 86Rb uptake of canine renal and femoral arteries

Journal Article · Fri Aug 01 04:00:00 EDT 1986 · Am. J. Physiol.; (United States)

OSTI ID:5118111

Navran, S S; Allen, J C

We have previously reported that various manifestations of the Na+ pump, such as ouabain binding, Na+-K+-ATPase, and /sup 86/Rb uptake, were similar in canine renal and femoral arteries. In this report we compare ouabain-sensitive /sup 86/Rb uptake in renal and femoral arteries under two selected conditions of intracellular Na+:low Na+ and Na+ loaded. When intracellular Na+ was low, the renal artery dissociation constant for Rb+ was 1.13 mM compared with the Na+-loaded condition of 2.49 mM. The femoral artery dissociation constant remained the same at both Na+ levels. The maximal rate of /sup 86/Rb uptake (Vmax) of the renal artery was the same at both Na+ levels, but the femoral artery Vmax was 23.6 and 11.11 nmol X mg-1 X 20 min-1 in Na+-loaded and low-Na+ vessels, respectively. The reason for the difference in Na+ pump regulation in these two vessels is not clear, but these results suggest that there are heterogeneous mechanisms for controlling ionic movements in vascular smooth muscle.

• Research Organization: Baylor College of Medicine, Houston, TX
• OSTI ID: 5118111
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States); ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ALKALI METALS
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DOGS
DRUGS
ELEMENTS
GLYCOSIDES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEMBRANE TRANSPORT
METALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OUABAIN
RADIOISOTOPES
RADIONUCLIDE KINETICS
RUBIDIUM 86
RUBIDIUM ISOTOPES
SODIUM
STROPHANTHINS
UPTAKE
VERTEBRATES