Thallium uptake by canine iliac arteries
Journal Article
·
· Hypertension (Dallas); (United States)
Most of the thallium uptake by canine iliac arteries (70%) was inhibited by ouabain. The component sensitive to ouabain was significantly increased by incubating tissues in K/sup +/-free solution and reduced by low temperatures, metabolic inhibitors, and loading with lithium. The apparent Km for thallium for the ouabain-sensitive uptake was 0.47 +/- 0.046 mM. External K/sup +/ inhibited thallium uptake and the apparent Ki was estimated to be 6.5 mM. Thallium thus appears to have a greater affinity for the ouabain-sensitive components. The residual component of thallium uptake was unaffected by maneuvers that affected the ouabain-sensitive uptake, which thus appears to be a suitable indicator of Na/sup +/ pump activity in vascular smooth muscle.
- Research Organization:
- McMaster Univ., Hamilton, Ontario, Canada
- OSTI ID:
- 5021485
- Journal Information:
- Hypertension (Dallas); (United States), Journal Name: Hypertension (Dallas); (United States) Vol. 5:4; ISSN HPRTD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CATIONS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLYCOSIDES
HEAVY NUCLEI
INHIBITION
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEMBRANE TRANSPORT
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OUABAIN
POTASSIUM COMPOUNDS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SODIUM COMPOUNDS
STROPHANTHINS
THALLIUM 201
THALLIUM ISOTOPES
UPTAKE
VERTEBRATES
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CATIONS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLYCOSIDES
HEAVY NUCLEI
INHIBITION
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEMBRANE TRANSPORT
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OUABAIN
POTASSIUM COMPOUNDS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SODIUM COMPOUNDS
STROPHANTHINS
THALLIUM 201
THALLIUM ISOTOPES
UPTAKE
VERTEBRATES