Treatment of endemic fluorosis in human beings: an experimental study
Short term in vitro studies showed that bone meal, serpentine, calcium chloride, egg-shell powder, Dowex and Gelusil were effective in removing fluoride from water high in fluoride naturally. Serpentine, when administered orally in 25 mg dosage twice a day to normal controls and 50 mg twice a day to patients with endemic skeletal fluorosis inhibited absorption of fluoride from the bowels. The urinary excretion of fluoride was increased in a patient with endemic skeletal fluorosis on a fluoride-free diet following the administration of serpentine. This increase suggested that serpentine had a direct effect on bone. The exact mechanism of this action and that of bone meal is not known. Further work on this aspect is in progress.
- Research Organization:
- Medical College, Meerut, India
- OSTI ID:
- 5116683
- Journal Information:
- Fluoride; (United States), Journal Name: Fluoride; (United States) Vol. 9:2; ISSN FLUOA
- Country of Publication:
- United States
- Language:
- English
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560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
ABSORPTION
ALKALINE EARTH METAL COMPOUNDS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CALCIUM CHLORIDES
CALCIUM COMPOUNDS
CALCIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
CHROMATOGRAPHY
CLEARANCE
DIET
DIGESTIVE SYSTEM
DISEASES
DRINKING WATER
EXCRETION
FLUORIDES
FLUORINE COMPOUNDS
GASTROINTESTINAL TRACT
HALIDES
HALOGEN COMPOUNDS
HYDROGEN COMPOUNDS
IN VITRO
INTESTINAL ABSORPTION
INTESTINES
ION EXCHANGE CHROMATOGRAPHY
ION EXCHANGE MATERIALS
LARGE INTESTINE
MATERIALS
MINERALS
ORGANIC COMPOUNDS
ORGANIC ION EXCHANGERS
ORGANIC POLYMERS
ORGANS
OXYGEN COMPOUNDS
PATIENTS
POLYMERS
POLYOLEFINS
POLYSTYRENE-DVB
SEPARATION PROCESSES
SERPENTINE
SILICATE MINERALS
SKELETAL DISEASES
THERAPEUTIC USES
THERAPY
TOXICITY
UPTAKE
URINE
USES
WASTES
WATER