Skeletal fluorosis: roentgenological and histopathological study
Detailed radiological and morphometrical studies have been reported in 100 patients of proven endemic skeletal fluorosis all of whom were symptomatic. Though the radiological features such as osteopetrosis, periosteal bone formation, osteophytosis and calcification of the interosseous membrane and ligaments remain the mainstay in the diagnosis of skeletal fluorosis, in increasing instances radiological findings have been variable and uncommon suggesting the presence of other metabolic bone disease. Morphometrical measurements of the iliac crest biopsies revealed osteoclastic resorption of the trabecular bone, increased numbers of resorption lacunae, periosteocytic osteolysis and increased osteoid covered surfaces. The calcification front had a normal distribution except in four patients with associated osteomalacia. Findings were similar in children suffering from endemic fluorosis. These studies suggest that the stabilizing effect of fluoride on bone due to the conversion of hydroxyapatite to fluorapatite produces a compensatory hyperplasia of the parathyroid glands. Thus, the possibility of a beneficial effect of fluoride in osteoporosis has been challenged in the light of this parathyroid compensation.
- Research Organization:
- Medical College, Meerut, India
- OSTI ID:
- 5089966
- Journal Information:
- Fluoride; (United States), Journal Name: Fluoride; (United States) Vol. 9:2; ISSN FLUOA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANIMAL TISSUES
ASIA
BIOLOGICAL EFFECTS
BIOMEDICAL RADIOGRAPHY
BODY
BODY AREAS
CALCINOSIS
CHILDREN
CONNECTIVE TISSUE
DEVELOPING COUNTRIES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE GLANDS
FLUORIDES
FLUORINE COMPOUNDS
GLANDS
HALIDES
HALOGEN COMPOUNDS
INDIA
LIGAMENTS
MEDICINE
NUCLEAR MEDICINE
ORGANS
OSTEOPOROSIS
PARATHYROID GLANDS
PATHOLOGICAL CHANGES
PATIENTS
PELVIS
RADIOLOGY
SKELETAL DISEASES
SKELETON
TISSUES