A human. alpha. -fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers
Journal Article
·
· Molecular and Cellular Biology; (United States)
- Snow Brand Milk Products Co., Ltd., Tochigi (Japan)
- Hyogo Coll. of Medicine (Japan)
- Univ. of Calgary, Alberta (Canada)
The authors have isolated a full-length cDNA encoding a protein (ATBF1) that binds to an AT-rich motif in the human {alpha}-fetoprotein gene enhancer. The amino acid sequence deduced from the cDNA revealed that this is the largest DNA-binding protein (306 kDa) known to date, containing four homeodomains, 17 zinc finger motifs, and a number of segments potentially involved in transcriptional regulation. Although the exact function of this protein has not been determined, these structural features suggest that ATBF1 plays a transcriptional regulatory role.
- OSTI ID:
- 5116311
- Journal Information:
- Molecular and Cellular Biology; (United States), Journal Name: Molecular and Cellular Biology; (United States) Vol. 11:12; ISSN MCEBD; ISSN 0270-7306
- Country of Publication:
- United States
- Language:
- English
Similar Records
Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with zinc-binding finger structure
Characterization and mapping of human genes encoding zinc finger proteins
Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures
Journal Article
·
Sat Oct 01 00:00:00 EDT 1988
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
·
OSTI ID:5606852
Characterization and mapping of human genes encoding zinc finger proteins
Journal Article
·
Thu Oct 31 23:00:00 EST 1991
· Proceedings of the National Academy of Sciences of the United States of America; (United States)
·
OSTI ID:5826543
Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures
Journal Article
·
Wed Jan 31 23:00:00 EST 1996
· Genomics
·
OSTI ID:508339