Isolation and mapping of a novel human gene encoding a protein containing zinc-finger structures
- Cancer Institute, Toshima-ku, Tokyo (Japan)
- Otsuka GEN Institute, Kawauchi-cho, Tokushima (Japan); and others
We have isolated and characterized a cDNA clone, termed OTK18, representing a novel human gene. The 3754 nucleotides of this clone contain an open reading frame of 2133 nucleotides. As the predicted 711-amino-acid protein contains 13 contiguous zinc-finger structures of the C{sub 2}H{sub 2} type, it would be expected to function as a DNA-binding multi-finger protein. The 4.3-kb transcript was expressed in all adult human tissues examined by Northern analysis. The gene was assigned to chromosomal band 19q13.4 by fluorescence in situ hybridization. 23 refs., 3 figs.
- OSTI ID:
- 508339
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 31; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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