Bioavailability indicators of inhaled cadmium compounds

Journal Article · Sun Jun 01 04:00:00 EDT 1986 · Ecotoxicol. Environ. Saf.; (United States)

DOI:https://doi.org/10.1016/0147-6513(86)90100-4· OSTI ID:5114780

Glaser, U; Kloeppel, H H; Hochrainer, D

In a thirty-day inhalation study male Wistar rats were continuously exposed to submicron aerosols of three different cadmium compounds. The cadmium chloride (CdCl/sub 2/) and cadmium oxide (CdO) aerosol concentrations were 0.1 mg/m3 Cd. Because of its lower solubility the cadmium sulfide (CdS) level was 1 mg/m3 Cd. For CdCl/sub 2/ and CdO, most of the cadmium was found in the lung cytosolic compartment, but for CdS only 30% of the cadmium was retrieved from the lung cytosols. This was observed both at the end of the inhalation and also after an additional 2-month period in fresh air. The cadmium contents of the lung homogenates, cytosols, and the lung cytosolic metallothionein were found to be twice as much for exposure to CdO than for exposure to CdCl/sub 2/. For exposure to CdS at cadmium concentrations 10 times higher the same cadmium levels were found as for CdO. These results are confirmed by results from alveolar lavage analysis indicating that in the lung-inhaled CdO is even more available to lung tissue than the very soluble CdCl/sub 2/, and CdO has an availability 10 times as much as CdS. This study proved that lung compartmental cadmium and metallothionein contents as well as lung lavage analysis can describe the bioavailability of inhaled cadmium.

• OSTI ID: 5114780
• Journal Information: Ecotoxicol. Environ. Saf.; (United States), Journal Name: Ecotoxicol. Environ. Saf.; (United States) Vol. 3; ISSN EESAD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL AVAILABILITY
BODY BURDEN
BRONCHI
CADMIUM
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM OXIDES
CADMIUM SULFIDES
CHALCOGENIDES
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
DISPERSIONS
ELEMENTS
HALIDES
HALOGEN COMPOUNDS
INHALATION
INORGANIC PHOSPHORS
INTAKE
MAMMALS
METALLOPROTEINS
METALLOTHIONEIN
METALS
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PARTICLE SIZE
PHOSPHORS
PROTEINS
RATS
RESPIRATORY SYSTEM
RODENTS
SIZE
SOLS
SULFIDES
SULFUR COMPOUNDS
VERTEBRATES