Effects of inhaled cadmium oxide on cadmium transfer across epithelial and endothelial structures of the lung

Conference · Sat Jan 01 04:00:00 EST 1983

OSTI ID:5920213

Oberdoerster, G; Morrow, P E

To investigate the transport of cadmium from lung into lymphatic and blood vessels, experiments in dogs were performed. Five mongrel dogs were exposed via face mask to CdO aerosols for 1 h/day, 5 days/week during a 6-week exposure period. Five unexposed dogs served as controls. CdO concentration was 1.3 mg/m/sup 3/, the particle size was 0.25 ..mu..m (mass median aerodynamic diameter, MMAD). Following this, /sup 109/Cd was instilled intrabronchially in acute experiments and lung-lymph outflow as well as blood /sup 109/Cd levels were determined. To correct for reabsorption from blood into lymph, /sup 115/CdCl/sub 2/ was given at a constant i.v. infusion rate and its levels in lymph and blood were monitored as well. With this double-isotope technique it was found that lymphatic clearance of cadmium from the lung increased three-fold after CdO pre-exposure. Also, after pre-exposure to CdO, significantly more of i.v. /sup 115/Cd appeared in lung lymph. It is concluded that: (1) clearance of cadmium from lungs into lymph is much less than into blood; (2) after inhalation exposure to Cd aerosols, the permeability of the lung vasculature to Cd increases and there is evidence that the permeability of the respiratory epithelium increases as well.

• Research Organization: Rochester Univ., NY (USA). Dept. of Radiation Biology and Biophysics
• DOE Contract Number: AC02-76EV03490
• OSTI ID: 5920213
• Report Number(s): DOE/EV/03490-2294; CONF-830918-1; ON: DE83013056
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CADMIUM
CADMIUM 109
CADMIUM 115
CADMIUM ISOTOPES
CARDIOVASCULAR SYSTEM
CLEARANCE
COLLOIDS
DATA
DAYS LIVING RADIOISOTOPES
DISPERSIONS
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
INFORMATION
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LUNGS
LYMPH VESSELS
LYMPHATIC SYSTEM
MAMMALS
MEMBRANE TRANSPORT
METALS
NUCLEI
NUMERICAL DATA
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
SOLS
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES