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Patterns of radiorace formation in yeast organisms. Report 11. Facts and hypotheses

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5111714
A hypothesis is expounded to explain the patterns of radiation-induced race formation in yeast. According to this hypothesis, the same primary lesions that elicit the lethal effect play the leading role in radiorace formation. Each such injury is absolutely lethal to haploid cells. In diploid cells, each injury elicits a lethal effect only with a certain degree of probability. The effects of different injuries are cumulative. If the cell sustains no damage, it will survive and originate a clone that does not differ from the control. If a cell sustains one or several injuries, it either perishes or originates a mutant or unstable clone. The greater the number of injuries in the original irradiated cell, the greater the instability of the clone; with a large enough number of injuries, all offspring of the irradiated cell perish. The lesions that have the above properties are most likely major chromosomal aberrations.
Research Organization:
All-Union Scientific Research Inst. of Genetics and Breeding of Commercial Microorganisms, Moscow
OSTI ID:
5111714
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:4; ISSN RADBA
Country of Publication:
United States
Language:
English