Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Dual tracer autoradiographic study of beta-methyl-(1-/sup 14/C) heptadecanoic acid and 15-p-(131I)-iodophenyl-beta-methylpentadecanoic acid in normotensive and hypertensive rats

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5094596
; ; ; ; ; ; ; ; ;

The myocardial distribution of 15-p-(/sup 131/I)iodophenyl-3-(R,S)-methylpentadecanoic acid (BMPDA) and 1(/sup 14/C)-3-(R,S)-methylheptadecanoic acid (BMHDA) was compared in normotensive and hypertensive rats using quantitative dual tracer autoradiographic techniques. The myocardial distribution of carbon-14 (/sup 14/C) BMHDA and iodine-131 (/sup 131/I) BMPDA was nearly homogeneous in the normotensive rats, while both tracers showed similar, though very heterogeneous, distribution in hypertensive hearts with decreased uptake in the endocardial region. Our data demonstrate that myocardial distribution of (/sup 131/I)BMPDA was essentially the same as (/sup 14/C)BMHDA, and thus single photon emission computed tomographic imaging with /sup 123/I-labeled BMPDA could be useful for the detection of regional changes of myocardial fatty acid uptake in patients with prolonged and severe hypertension.

OSTI ID:
5094596
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 7; ISSN JNMEA
Country of Publication:
United States
Language:
English

Similar Records

Comparative dual tracer studies of. beta. -methyl-(1-C-14)heptadecanoic acid (BMHDA) and 15-p-(I-131)-iodophenyl-. beta. -methyl pentadecanoic acid (BMPDA) in hypertensive rats
Conference · Sat Dec 31 23:00:00 EST 1983 · J. Nucl. Med.; (United States) · OSTI ID:6590984
Quantitative autoradiographic measurement of regional myocardial substrate uptake in hypertensive rats
Conference · Sat Dec 31 23:00:00 EST 1983 · J. Nucl. Med.; (United States) · OSTI ID:6860554
Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted alpha- and beta-methyl-branched fatty acids
Journal Article · Wed Feb 29 23:00:00 EST 1984 · J. Med. Chem.; (United States) · OSTI ID:6847258

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
HEART
HYPERTENSION
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES