Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Postradiation sarcoma involving the spine

Journal Article · · Neurosurgery; (United States)
; ; ; ;
Postradiation sarcomas arising many years after treatment of cancer are long term sequelae of therapy. We describe the clinical features, radiographic findings, and results of treatment in 13 patients with such sarcomas encountered over a 6-year period. Of these patients, 9 had bone sarcomas and the remaining 4 had paraspinal tumors arising from adjacent soft tissue and nerve. The primary cancer for which radiation was given included Hodgkin's disease (4 patients), breast cancer (2 patients), cervix cancer (2 patients), and a variety of others (5 patients). The latent interval to the occurrence of the second neoplasm varied from 6 to 30 years (median, 10 years) after treatment of the original tumor. Despite aggressive treatment, the overall prognosis was poor. The median survival was 8 months, with only 3 surviving more than 2 years. Although rare, postradiation sarcoma should be considered in the differential diagnosis of patients presenting with late onset of spinal pain or neurological symptoms after clinical remission of an original cancer.
Research Organization:
St. Lukes/Roosevelt Hospital Center, New York, NY
OSTI ID:
5091165
Journal Information:
Neurosurgery; (United States), Journal Name: Neurosurgery; (United States) Vol. 6; ISSN NRSRD
Country of Publication:
United States
Language:
English

Similar Records

Postradiation sarcoma of bone: review of 78 Mayo Clinic cases
Journal Article · Fri May 01 00:00:00 EDT 1981 · Mayo Clin., Proc.; (United States) · OSTI ID:5638235
Postradiation sarcomas of bone
Journal Article · Sat Oct 01 00:00:00 EDT 1988 · Health Phys.; (United States) · OSTI ID:6541028
POSTRADIATION OSTEOGENIC SARCOMA. REPORT OF A CASE AND REVIEW OF LITERATURE
Journal Article · Fri Jun 01 00:00:00 EDT 1962 · Am. J. Roentgenol., Radium Therapy Nuclear Med. · OSTI ID:4818519

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
CENTRAL NERVOUS SYSTEM
DELAYED RADIATION EFFECTS
DISEASES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SIDE EFFECTS
SKELETON
SPINAL CORD
SURVIVAL TIME
THERAPY