Postradiation sarcomas of bone

Journal Article · Sat Oct 01 00:00:00 EDT 1988 · Health Phys.; (United States)

DOI:https://doi.org/10.1097/00004032-198810000-00004· OSTI ID:6541028

Huvos, A G; Woodard, H Q

Fifty-nine patients with osteogenic sarcomas arising in bones following exposure to x rays and 20 patients with postradiation malignant fibrous histiocytomas of bone arising as a direct consequence of irradiation were studied. These represent 5.5% of all osteogenic sarcomas and 4.9% of all malignant fibrous histiocytomas of bones. The sarcomas may affect any skeletal site, but most commonly they arose in bones of the pelvic and shoulder girdles or the distal end of the femur. Grounds for irradiation were either nonosseous conditions or preexistent skeletal lesions. Reasons for incidental osseous irradiation included Hodgkin's disease, carcinoma of cervix, breast or lung; bilateral retinoblastoma and others, and giant cell tumor predominated among the irradiated skeletal lesions. The mean and the median radiation doses were 6040 cGy (rad) and 5700 cGy (rad), respectively. The period of latency between irradiation and the appearance of the bone sarcoma ranged from 3.5 to 47 y with a mean of 16.5 and median of 14.5, respectively. The cumulative disease-free survival rate for malignant fibrous histiocytoma patients at 3 y was 58%. The cumulative disease-free survival rate at 5 y for patients with osteogenic sarcoma was 17%, with a median survival estimate of 1 y. Although all patients with malignant fibrous histiocytoma who received their radiation therapy for a preexistent bone lesion survived, only 27% of the patients whose bone was normal at the time of irradiation are alive and well at the 3-y mark.

• Research Organization: Memorial Hospital for Cancer and Allied Diseases, New York, NY (USA)
• OSTI ID: 6541028
• Journal Information: Health Phys.; (United States), Vol. 55:4
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OSTEOSARCOMAS
RADIOINDUCTION
RADIOTHERAPY
SIDE EFFECTS
SKELETON
BIOLOGICAL RADIATION EFFECTS
PATIENTS
RADIATION DOSES
SURVIVAL CURVES
X RADIATION
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BODY
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ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MEDICINE
NEOPLASMS
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RADIATIONS
RADIOLOGY
SARCOMAS
SKELETAL DISEASES
THERAPY
560151* - Radiation Effects on Animals- Man