Anti-inflammatory drug (BW755C) inhibits airway hyperresponsiveness induced by ozone in dogs

Journal Article · Thu Aug 01 04:00:00 EDT 1985 · J. Allergy Clin. Immunol.; (United States)

DOI:https://doi.org/10.1016/0091-6749(85)90695-5· OSTI ID:5091117

Fabbri, L M; Aizawa, H; O'Byrne, P M; Bethel, R A; Walters, E H; Holtzman, M J; Nadel, J A

To follow up a previous observation that airway hyperresponsiveness induced by ozone is linked to airway inflammation, the authors investigated the effect of BW755C, an anti-inflammatory drug, on ozone-induced hyperresponsiveness in dogs. Airway responsiveness was assessed with dose-response curves of acetylcholine aerosol versus pulmonary resistance in two sets of experiments. In one set (placebo treatment), five dogs were given only saline solution treatment and were studied before treatment or ozone exposure and then after treatment both before and after ozone (3.0 ppm, 2 hours); in another set (BW755C treatment), the same dogs were studied before BW755C treatment or ozone and then after treatment (10 mg/kg intravenously) both before and after ozone. When the dogs were given no BW755C treatment, ozone induced a marked increase in airway responsiveness to acetylcholine. When the dogs were given BW755C, responsiveness was no different during treatment than before treatment but, more importantly, responsiveness did not increase significantly after ozone. The authors conclude that BW755C markedly inhibits ozone-induced airway hyperresponsiveness in dogs, probably by inhibiting the formation of oxygenation products of arachidonic acid.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 5091117
• Journal Information: J. Allergy Clin. Immunol.; (United States), Journal Name: J. Allergy Clin. Immunol.; (United States); ISSN JACIB
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
ARACHIDONIC ACID
AZOLES
CARBOXYLIC ACIDS
DISEASES
DOGS
DOSE-RESPONSE RELATIONSHIPS
HETEROCYCLIC COMPOUNDS
MAMMALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OZONE
POLLUTION
PYRAZOLES
RESPIRATORY SYSTEM DISEASES
RESPONSE MODIFYING FACTORS
SYNERGISM
TOXICITY
VERTEBRATES