Importance of airway inflammation for hyperresponsiveness induced by ozone. [Dogs]

Journal Article · Wed Jun 01 04:00:00 EDT 1983 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5125807

Holtzman, M J; Fabbri, L M; O'Byrne, P M; Gold, B D; Aizawa, H; Walters, E H; Alpert, S E; Nadel, J A

We studied whether ozone-induced airway hyperresponsiveness correlates with the development of airway inflammation in dogs. To assess airway responsiveness, we determined increases in pulmonary resistance produced by delivering acetylcholine aerosol to the airways. To assess airway inflammation, we biopsied the airway mucosa and counted the number of neutrophils present in the epithelium. Airway responsiveness and inflammation were assessed in anesthetized dogs before ozone exposure and then 1 h and 1 wk after ozone (2.1 ppm, 2 h). Airway responsiveness increased markedly at 1 h after ozone and returned to control levels 1 wk later in each of 6 dogs, but it did not change after ozone in another 4 dogs. Furthermore, dogs that became hyperresponsive also developed a marked and reversible increase in the number of neutrophils in the epithelium, whereas dogs that did not become hyperresponsive had no change in the number of neutrophils. For the group of dogs, the level of airway responsiveness before and after ozone exposure correlated closely with the number of epithelial neutrophils. The results suggest that ozone-induced airway hyperresponsiveness may depend on the development of an acute inflammatory response in the airways.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 5125807
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 127:6; ISSN ARRDA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETYLCHOLINE
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOPSY
BLOOD
BLOOD CELLS
BODY FLUIDS
DIAGNOSTIC TECHNIQUES
DOGS
DRUGS
ESTERS
INFLAMMATION
LEUKOCYTES
MAMMALS
MATERIALS
MEMBRANES
MUCOUS MEMBRANES
NEUROREGULATORS
NEUTROPHILS
ORGANIC COMPOUNDS
OZONE
PARASYMPATHOMIMETICS
PATHOLOGICAL CHANGES
QUATERNARY COMPOUNDS
RESPIRATORY SYSTEM
SYMPTOMS
VERTEBRATES