Cold exposure potentiates the effect of insulin on in vivo glucose uptake

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · American Journal of Physiology; (USA)

OSTI ID:5084745

Vallerand, A L; Perusse, F; Bukowiecki, L J ^[1]

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1. Laval Univ. School of Medicine, Quebec (Canada)

The effects of cold exposure and insulin injection on the rates of net 2-({sup 3}H)deoxyglucose uptake (K{sub i}) in peripheral tissues were investigated in warm-acclimated rats. Cold exposure and insulin treatment independently increased K{sub i} values in skeletal muscles, heart, white adipose tissue, and brown adipose tissue. The effects of cold exposure were particularly evident in brown adipose tissue where the K{sub i} increased >100 times. When the two treatments were combined, it was found that cold exposure synergistically enhanced the maximal insulin responses for glucose uptake in brown adipose tissue, all white adipose tissue depots, and skeletal muscles investigated. The results indicate that cold exposure induces an insulin-like effect on K{sub i} that does not appear to be specifically associated with shivering thermogenesis in skeletal muscles, because that effect was observed in all insulin-sensitive tissues. The data also demonstrate that cold exposure significantly potentiates the maximal insulin responses for glucose uptake in the same tissues. This potentialization may result from (1) an enhanced responsiveness of peripheral tissues to insulin, possibly occurring at metabolic steps lying beyond the insulin receptor and (2) an increased tissue blood flow augmenting glucose and insulin availability and thereby amplifying glucose uptake.

• OSTI ID: 5084745
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 253:2; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ALDEHYDES
ANIMAL TISSUES
ANIMALS
BIOCHEMICAL REACTION KINETICS
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
CONNECTIVE TISSUE
DISACCHARIDES
GLUCOSE
HEXOSES
HORMONES
HYDROGEN COMPOUNDS
INSULIN
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
METABOLISM
MONOSACCHARIDES
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PROTEINS
RATS
REACTION KINETICS
RECEPTORS
RODENTS
SACCHARIDES
SACCHAROSE
TEMPERATURE EFFECTS
TISSUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES
VOLUME