The protein tyrosine phosphatase {epsilon} gene maps to mouse chromosome 7 and human chromosome 10q26
- Harvard Medical School, Boston, MA (United States)
- National Institutes of Health Bethesda, MD (United States); and others
We have mapped the mouse protein tyrosine phosphatase {epsilon} (PTP{epsilon}, gene symbol PTPRE) gene to the distal region of chromosome 7 by linkage analysis using two sets of multilocus genetic crosses. The human PTP{epsilon} gene (gene symbol PTPRE) was mapped to chromosome 10q26 by fluorescence in situ hybridization. We have previously documented the existence of two isoforms of PTP{epsilon}--a transmembranal, receptor-type isoform and a shorter, cytoplasmic one. Both isoforms have been suggested to arise from a single gene through the use of alternative promoters and 5{prime} exons. The identification of a single PTP{epsilon} locus in both organisms is consistent with this suggestion. 12 refs., 2 figs.
- OSTI ID:
- 508338
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 31; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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