Receptor protein-tyrosine phosphatase. gamma. is a candidate tumor suppressor gene at human chromosome region 3p21

Journal Article · Sat Jun 01 04:00:00 EDT 1991 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.88.11.5036· OSTI ID:6057448

LaForgia, S; Cannizzaro, L A; Boghosian-Sell, L; Croce, C M; Huebner, K ^[1]; Morse, B ^[2]; Levy, J; Barnea, G; Schlessinger, J ^[3]; Li, F ^[4]; Nowell, P C; Glick, J ^[5]; Weston, A; Harris, C C ^[6]; Drabkin, H ^[7]; Patterson, D ^[8]

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1. Temple Univ. School of Medicine, Philadelphia, PA (United States)
2. Rhone-Poulenc Rorer Central Research, King of Prussia, PA (United States)
3. New York Univ. Medical Center, NY (United States)
4. Dana-Farber Cancer Inst., Boston, MA (United States)
5. Univ. of Pennsylvania School of Medicine, Philadelphia (United States)
6. National Cancer Inst., Bethesda, MD (United States)
7. Univ. of Colorado Health Sciences Center, Denver (United States)
8. Eleanor Roosevelt Inst., Denver, CO (United States)

PTPG, the gene for protein-tyrosine phosphatase {gamma} (PTP{gamma}), maps to a region of human chromosome 3, 3p21, that is frequently deleted in renal cell carcinoma and lung carcinoma. One of the functions of protein-tyrosine phosphatases is to reverse the effect of protein-tyrosine kinases, many of which are oncogenes, suggesting that some protein-tyrosine phosphatase genes may act as tumor suppressor genes. A hallmark of tumor suppressor genes is that they are deleted in tumors in which their inactivation contributes to the malignant phenotype. In this study, one PTP {gamma} allele was lost in 3 of 5 renal carcinoma cell lines and 5 of 10 lung carcinoma tumor samples tested. Importantly, one PTP {gamma} allele was lost in three lung tumors that had not lost flanking loci. PTP {gamma} mRNA was expressed in kidney cell lines and lung cell lines but not expressed in several hematopoietic cell lines tested. Thus, the PTP {gamma} gene has characteristics that suggest it as a candidate tumor suppressor gene at 3p21.

• OSTI ID: 6057448
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 88:11; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMAL CELLS
BODY
CARBOXYLIC ACIDS
CARCINOMAS
CELL PROLIFERATION
CHROMOSOMES
DISEASES
ENZYMES
ESTERASES
GENES
GENETIC MAPPING
HUMAN CHROMOSOME 21
HUMAN CHROMOSOMES
HYDROLASES
HYDROXY ACIDS
KIDNEYS
LUNGS
MAPPING
MEMBRANE PROTEINS
MESSENGER-RNA
NEOPLASMS
NUCLEIC ACIDS
ONCOGENES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHOSPHATASES
PROTEINS
RECEPTORS
RESPIRATORY SYSTEM
RNA
TUMOR CELLS
TYROSINE