Chromosomal location of murine protein tyrosine phosphatase (Ptprj and Ptpre) genes
- Univ. of Tokyo, Bunkyo-ku (Japan); and others
It is now widely accepted that protein tyrosine phosphatases (PTPases) play important or even critical roles in cell growth, differentiation, and development. Our recent experiments suggested that specific PTPases, PTP{beta}2 and PTP{epsilon}, are involved in the early molecular events for in vitro differentiation of mouse erythroleukemia (MEL) as well as embryonic carcinoma (F9) cells. Using mouse cDNA for PTP{beta}2 and PTP{epsilon}, which we have cloned recently, we attempted to locate the genes to mouse chromosomes. Interspecific backcross analysis indicated that the gene for PTP{beta}2, Ptprj, is located in the middle region of chromosome 2, and the gene for PTPL{epsilon}, Ptpre, was mapped in the vicinity of the imprinted regions in the distal part of chromosome 7. Possible biological roles of these PTPases are discussed. 14 refs., 2 figs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 443885
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 29; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
Similar Records
Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci
The protein tyrosine phosphatase {epsilon} gene maps to mouse chromosome 7 and human chromosome 10q26
Isolation and mapping of human T-cell protein tyrosine phosphatase sequences: Localization of genes and pseudogenes discriminated using fluorescence hybridization with genomic versus cDNA probes
Journal Article
·
Thu Aug 10 00:00:00 EDT 1995
· Genomics
·
OSTI ID:390666
The protein tyrosine phosphatase {epsilon} gene maps to mouse chromosome 7 and human chromosome 10q26
Journal Article
·
Wed Jan 31 23:00:00 EST 1996
· Genomics
·
OSTI ID:508338
Isolation and mapping of human T-cell protein tyrosine phosphatase sequences: Localization of genes and pseudogenes discriminated using fluorescence hybridization with genomic versus cDNA probes
Journal Article
·
Tue Jun 01 00:00:00 EDT 1993
· Genomics; (United States)
·
OSTI ID:7077025