Clearance of polonium-210-enriched cigarette smoke from the rat trachea and lung
The distribution and clearance of alpha radioactivity in the lungs of rats were measured after inhalation of smoke from cigarettes highly enriched in /sup 210/Po. Female Fischer rats were exposed daily for 6 months to smoke from cigarettes with 500 times the normal content of /sup 210/Po. Control rats were exposed to standard cigarette smoke. Animals were serially withdrawn and killed. After necropsy the trachea, major bronchi, larynx, and nasopharynx were examined for surface alpha activity by an etched track technique utilizing cellulose nitrate detectors. Areas of accumulated activity were seen on samples of larynx from rats exposed to the /sup 210/Po-enriched cigarettes. No other local accumulations were seen on the airways. The lower lungs were analyzed radiochemically for /sup 210/Po. Both radiochemical analysis and track measurements showed highly elevated activity concentrations in rats exposed to the /sup 210/Po-enriched cigarettes. Following withdrawal from smoking, both short- and long-term clearance components were seen. The parameters which fit the postexposure data for clearance of the lung burden cannot fit the buildup during the exposure period.
- OSTI ID:
- 5076326
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
TOBACCO SMOKES
LUNG CLEARANCE
TISSUE DISTRIBUTION
BODY BURDEN
INHALATION
LARYNX
LUNGS
POLONIUM 210
RATS
TRACHEA
AEROSOLS
ALPHA DECAY RADIOISOTOPES
ANIMALS
BODY
CLEARANCE
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISPERSIONS
DISTRIBUTION
EVEN-EVEN NUCLEI
EXCRETION
HEAVY NUCLEI
INTAKE
ISOTOPES
MAMMALS
NUCLEI
ORGANS
POLONIUM ISOTOPES
RADIOISOTOPES
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SMOKES
SOLS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques