Tissue distribution of subcutaneously administered aluminum chloride in weanling rabbits
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
The purpose of the investigation was to determine blood and tissue levels of aluminum (Al) in normal young rabbits. Furthermore, tissue distribution and accumulation of Al were determined as related to blood concentration in Al-dosed rabbits. The levels of Al accumulated were determined in different tissues of growing rabbits after continuous subcutaneous administration of Al chloride (3.78 mg/d) for 28 d. No signs of toxicity were apparent from comparisons of hematocrit or weight gain between control and Al-dosed rabbits. The largest concentration of the Al was observed in bone, which was also found to have the highest levels in the control rabbit tissues. Following bone, the experimental animals showed the greatest increase of Al levels in kidney cortex, kidney medulla, liver, testes, skeletal muscle, heart, brain white matter, and brain hippocampus, in that order. No significant difference was found in brain grey matter between control and experimental animals. As the brain tissue of the Al-treated animals had the lowest Al level of the tissues measured, it appears that there is a partial blood-brain barrier to entry of Al.
- Research Organization:
- North Carolina State Univ., Raleigh
- OSTI ID:
- 5073225
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 19:1; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ALUMINIUM
ALUMINIUM CHLORIDES
ALUMINIUM COMPOUNDS
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD-BRAIN BARRIER
BODY
BODY FLUIDS
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
EXPERIMENTAL DATA
GLANDS
GONADS
HALIDES
HALOGEN COMPOUNDS
HEART
INFORMATION
INJECTION
INTAKE
KIDNEYS
LIVER
MALE GENITALS
MAMMALS
MATERIALS
METALS
MUSCLES
NERVOUS SYSTEM
NUMERICAL DATA
ORGANS
RABBITS
SKELETON
SUBCUTANEOUS INJECTION
TESTES
TISSUE DISTRIBUTION
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ALUMINIUM
ALUMINIUM CHLORIDES
ALUMINIUM COMPOUNDS
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD-BRAIN BARRIER
BODY
BODY FLUIDS
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
EXPERIMENTAL DATA
GLANDS
GONADS
HALIDES
HALOGEN COMPOUNDS
HEART
INFORMATION
INJECTION
INTAKE
KIDNEYS
LIVER
MALE GENITALS
MAMMALS
MATERIALS
METALS
MUSCLES
NERVOUS SYSTEM
NUMERICAL DATA
ORGANS
RABBITS
SKELETON
SUBCUTANEOUS INJECTION
TESTES
TISSUE DISTRIBUTION
VERTEBRATES