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A toxicological study of 5,6,7,8 tetrafluoro- 1,4-benzodioxin

Technical Report ·
OSTI ID:5067183
The acute oral LD/sub 50/ values for 5,6,7,8 tetrafluro-1,4 benzodioxin for mice and rats are less than 5 gkg. According to classical guidelines, the material is considered slightly toxic in both species. The sensitization study in the guinea pig did not show the material to have potential sensitizing properties. Skin application studies on the rabbit demonstrated that it was cutaneously mildly irritating. This material was very mildly irritating in the rabbit eye application studies. 4 refs., 2 tabs.
Research Organization:
Los Alamos National Lab., NM (USA)
DOE Contract Number:
W-7405-ENG-36
OSTI ID:
5067183
Report Number(s):
LA-11168-MS; ON: DE88009069
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
DOSES
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
LETHAL DOSES
MAMMALS
MICE
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RABBITS
RATS
RODENTS
SKIN ABSORPTION
TOXICITY
UPTAKE
VERTEBRATES