Mutagenesis and differentiation induction in mammalian cells by environmental chemicals

Conference · Tue Jan 01 04:00:00 EST 1980

OSTI ID:5059595

Friedman, J.; Huberman, E.

These studies indicate that in agreement with the somatic mutation hypothesis, chemical carcinogens: (1) are mutagenic for mammalian cells as tested in the cell-mediated assay; (2) the degree of mutagenicity is correlated with their degree of carcinogenicity; (3) that at least in cases when analyzed carefully the metabolites responsible for mutagenesis are also responsible for initiating the carcinogenic event; and (4) that a cell organ type specificity can be established using the cell-mediated assay. Studies with HL-60 cells and HO melanoma cells and those of others suggest that tumor-promoting phorbol diesters can alter cell differentiation in various cell types and that the degree of the observed alteration in the differentiation properties may be related to the potency of the phorbol esters. Thus these and similar systems may serve as models for both studies and identification of certain types of tumor promoting agents. (ERB)

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5059595
• Report Number(s): CONF-800498-2
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
550900 -- Pathology
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
CARCINOGENESIS
CARCINOGENS
CELL CULTURES
CELL DIFFERENTIATION
CORRELATIONS
ESTERS
METABOLITES
MUTAGENESIS
ORGANIC COMPOUNDS
PATHOGENESIS
PHORBOL ESTERS
PROMOTERS
SPECIFICITY
TUMOR CELLS
TUMOR PROMOTERS