Effects of dietary and inhalative cadmium on hemoglobin and hematocrit in rats

Journal Article · Sun May 01 00:00:00 EDT 1977 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01685982· OSTI ID:5042444

Prigge, E; Baumert, H P; Muhle, H

Th dfference of the effects of dietary and inhalative cadmium on hemoglobin and hematocrit was investigated using Wistar male rats. For the inhalation studies, rats were exposed to CdCl/sub 2/ aerosols (0.2 mg Cd/m/sup 3/) for 66 days. For the dietary experiments the rats received 25, 50 and 100 ppM cadmium as CdCl/sub 2/ in drinking water. The following parameters were measured: the body weights of the animals, hematocrit and hemoglobin in blood, and the Cd content of liver and kidney. The results showed a retardation of growth in the aerosol-exposed group and the group with 100 ppM oral Cd intake. The relation of the Cd content of kidney to liver averaged 1.7 for the oral-exposed groups and 4.4 for the inhalation-exposed groups. The hematocrit and hemoglobin values for the inhalation-exposed rats showed no significant differences when compared to the controls, but the values for the dietary cadmium group showed a significant reduction.

• Research Organization: Institut fuer Aerobiologie, Grafschaft, Ger.
• OSTI ID: 5042444
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 17:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
BIOLOGICAL EFFECTS
AEROSOLS
BIOLOGICAL ACCUMULATION
BLOOD
CADMIUM CHLORIDES
GROWTH
HEMATOLOGY
HEMOGLOBIN
INHALATION
KIDNEYS
LIVER
ORAL ADMINISTRATION
RATS
WEIGHT
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARBOXYLIC ACIDS
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
ELEMENTS
GLANDS
GLOBIN
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INTAKE
MAMMALS
MEDICINE
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PORPHYRINS
PROTEINS
RODENTS
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)