Chelatable fraction of /sup 203/Pb in blood of young and adult rats
The binding of lead in the blood of young and adult rats was studied. A single intravenous dose of lead citrate (0.5 mg/kg) labeled with /sup 203/Pb was given to 2-week-old suckling rats and 19-week-old female albino rats. The whole blood content and distribution of lead between plasma and blood cells were measured 24 h later. The chelatable fraction of lead was estimated in vitro by incubating the blood cells of young and adult rats with a combination of chelating agents - EDTA plus BAL (0.4 mmole). This experiment revealed that young rats accumulated a higher percentage of the lead dose in whole blood in comparison to adults. The results of distribution of lead between plasma and blood cells showed that young rats had a higher content of lead in plasma. The chelatable fraction of lead bound to blood cells was almost three times greater in immature animals than in adults. It is concluded that lead binding in blood basically differs between young and adult rats probably due to the existence of different lead-binding ligands.
- Research Organization:
- University Hospital, Zagreb, Yugoslavia
- OSTI ID:
- 5024189
- Journal Information:
- Environ. Res.; (United States), Vol. 21:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BAL
BIOLOGICAL EFFECTS
EDTA
LEAD COMPOUNDS
METABOLISM
AGE DEPENDENCE
BLOOD CELLS
BLOOD PLASMA
CHELATES
COMPARATIVE EVALUATIONS
INTRAVENOUS INJECTION
LABELLED COMPOUNDS
LEAD 203
LIGANDS
RATS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATING AGENTS
COMPLEXES
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DITHIOLS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HEAVY NUCLEI
INJECTION
INTAKE
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEAD ISOTOPES
MAMMALS
MATERIALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
REAGENTS
RESPONSE MODIFYING FACTORS
RODENTS
SECONDS LIVING RADIOISOTOPES
THIOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551001 - Physiological Systems- Tracer Techniques