Proposed role of metallothionein in the transport of cadmium
In order to test a possible role of MT in the transport of Cd from liver to kidney, we compared the distribution of /sup 109/Cd administered either in the form of CdCl/sub 2/ or CdMT. Unlike in earlier studies which employed relatively massive amounts of Cd, in the present studies a low total amount of Cd (15 to 30 ..mu..g) was continuously infused over a period of 2 to 3 days. Results confirmed a preferential renal accumulation of CdMT. High intracellular renal and hepatic MT concentrations, induced by repeated prior injections of Cd, Zn, or Hg, did not alter the tissue distribution of infused CdCl/sub 2/ or CdMT. It is interesting to note that in some further experiments, equivalent amounts of extracellular MT depressed renal uptake of CdMT. These findings are consistent with a role of MT in the transport of Cd from liver to kidney.
- Research Organization:
- Univ. of Cincinnati Coll. of Medicine, OH
- OSTI ID:
- 5024154
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 21:2; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL ACCUMULATION
BODY
CADMIUM
CADMIUM 109
CADMIUM COMPOUNDS
CADMIUM ISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
KINETICS
LABELLED COMPOUNDS
LIVER
MERCURY
METABOLISM
METALS
NUCLEI
ORGANS
RADIOISOTOPES
REACTION KINETICS
RESPONSE MODIFYING FACTORS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES
ZINC