Retention of plutonium in the beagle after gastrointestinal absorption

Journal Article · Wed Feb 01 04:00:00 EST 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576287· OSTI ID:5019173

Toohey, R E; Bhattacharyya, M H; Oldham, R D; Larsen, R P; Moretti, E S

A 0.01 M bicarbonate solution containing 130 nCi (approx.5 kBq) of /sup 237/Pu (90% hexavalent, 93% ultrafilterable) was administrative via gelatin capsule to six adult male beagles following a 21-hr fast. The dogs were sacrificed after 5-6 weeks and the percentage of the administered plutonium retained in the liver plus skeleton and its distribution within the skeleton were determined. The mean amount retained in these tissues was (0.063 +/- 0.006)% of the administered dose. The mean amounts of plutonium in the liver and the skeleton were approximately equal, and the distribution within the skeleton was similar to that observed by other workers following either intravenous injection or inhalation. Our value for plutonium retention by the dog is about a factor of three less than the values we have reported for rodents. It is a factor of 7 greater than the product of the values for gastrointestinal absorption (f/sub 1/) and fractional retention (f/sub 2/) recommended by the ICRP for man.

• Research Organization: Argonne National Lab., IL
• OSTI ID: 5019173
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 97:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BODY
CARBON COMPOUNDS
CARBONATES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
GASTROINTESTINAL TRACT
GLANDS
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINAL ABSORPTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIVER
MAMMALS
NUCLEI
ORGANS
OXYGEN COMPOUNDS
PLUTONIUM 237
PLUTONIUM CARBONATES
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION FUNCTIONS
SECONDS LIVING RADIOISOTOPES
SKELETON
TISSUE DISTRIBUTION
TRANSURANIUM COMPOUNDS
UPTAKE
VERTEBRATES