Ewing's sarcoma. Radiographic pattern of healing and bony complications in patients with long-term survival

Journal Article · Tue Oct 01 04:00:00 EDT 1991 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19911001)68:7<1531::AID-CNCR2820680712>3.0.CO;2-T· OSTI ID:5018629

Ehara, S; Kattapuram, S V; Egglin, T K ^[1]

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1. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston (United States)

The radiographic appearance of Ewing's sarcoma was studied retrospectively in 22 patients who survived 5 years or longer after diagnosis and treatment. Expected changes from treatment, including regression of the extraosseous soft tissue mass, periostitis, and reconstitution of the cortex, occurred in all patients. Local recurrence occurred in one patient 10 years after complete remission whereas secondary osteosarcoma occurred more than 5 years after complete remission in two other cases. Both recurrent and secondary tumors presented as new lytic foci at the site of the original primary lesion. Lytic changes from radiation (radiation osteitis) may develop more than 2 years after treatment and in this sample; such findings were widely distributed in the radiation port. The authors conclude that bone remodeling and postradiation changes occur slowly over 2 years after treatment, and that any localized lysis at the primary site is suspicious for recurrence or secondary neoplasm. Knowledge of the expected changes and patterns of local recurrence and secondary neoplasms helps one to detect any significant change in its early phase.

• OSTI ID: 5018629
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 68:7; ISSN 0008-543X; ISSN CANCA
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DELAYED RADIATION EFFECTS
DISEASES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
OSTEOSARCOMAS
PATIENTS
POST-IRRADIATION EXAMINATION
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SIDE EFFECTS
SKELETAL DISEASES
SKELETON
SURVIVAL CURVES
THERAPY