Radiation-induced sarcoma of bone: CT findings in 19 cases

Journal Article · Sun Oct 01 04:00:00 EDT 1989 · AJR, American Journal of Roentgenology; (USA)

DOI:https://doi.org/10.2214/ajr.153.4.791· OSTI ID:5478570

Lorigan, J G; Libshitz, H I; Peuchot, M ^[1]

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1. Univ. of Texas M.D. Anderson Cancer Center, Houston (USA)

We reviewed the CT findings in 19 cases of radiation-induced sarcoma of bone. The latent period before development of the sarcoma ranged from 5 to 50 years (mean, 17 years). In all 19 lesions, a soft-tissue extraosseous component was seen on CT, and 18 of them had associated bone destruction. Expansion of the affected bone and tumor-matrix mineralization each were present in 10 patients, but occurred together in only five patients. Periosteal reaction was seen in five patients, one of whom had an associated fracture. Radiation osteitis could not be identified on CT scans in the affected bone of any of the patients when tumor was present, but it was present in contiguous bone in two patients and had been shown 6 years before tumor became apparent in the affected bone in one other patient. Radiation-induced sarcoma of bone should be considered when bone destruction and an associated soft-tissue mass are shown on CT, or when changes occur in the appearance of previously stable irradiated bone.

• OSTI ID: 5478570
• Journal Information: AJR, American Journal of Roentgenology; (USA), Journal Name: AJR, American Journal of Roentgenology; (USA) Vol. 153:4; ISSN AAJRD; ISSN 0361-803X
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPUTERIZED TOMOGRAPHY
DELAYED RADIATION EFFECTS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
OSTEOSARCOMAS
PATIENTS
PRIMATES
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SIDE EFFECTS
SKELETAL DISEASES
SKELETON
THERAPY
TOMOGRAPHY
VERTEBRATES