Oral bioavailability of chromium from a specific site

Journal Article · Wed May 01 04:00:00 EDT 1991 · Environmental Health Perspectives; (United States)

DOI:https://doi.org/10.2307/3431145· OSTI ID:5011120

Witmer, C M; Harris, R ^[1]; Shupack, S I ^[2]

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1. Rutgers, The State Univ. of New Jersey, Piscataway (United States)
2. Villanova Univ., PA (United States)

Analysis of soil from a specific site in New Jersey indicated a low level of sodium and chromium present as a calcium compound. Chromium was then administered orally to young, mature male rats at a level of 240 {mu}g/kg for 14 days as chromium-contaminated soil, as CaCrO{sub 4}, and as an equimolar mixture of the soil and calcium salts for 14 days. The rats were sacrificed 24 hours after the last dosing, and tissues were taken immediately for chromium analysis. Blood, muscle, and liver contained the highest levels of chromium in these animals, although kidney contained the highest concentration per gram of tissue. Total amount of chromium in the tissues was less than 2% of the administered chromium. In a study of the excretion of chromium, the animals were dosed orally for 8 days and the chromium in feces and urine was determined on days 1, 2, 7, and 8. The animals administered the chromium in soil had higher levels of chromium in both urine and feces on all days compared to the group fed the CaCrO{sub 4}. The total recovery of chromium in any of the 2-day periods was less than 50% of the chromium administered during that period.

• OSTI ID: 5011120
• Journal Information: Environmental Health Perspectives; (United States), Journal Name: Environmental Health Perspectives; (United States) Vol. 92; ISSN 0091-6765; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL AVAILABILITY
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHEMICAL ANALYSIS
CHROMATES
CHROMIUM COMPOUNDS
CLEARANCE
DEVELOPED COUNTRIES
DISTRIBUTION
EXCRETION
FECES
FEDERAL REGION II
MATERIALS
NEW JERSEY
NORTH AMERICA
ORAL ADMINISTRATION
OXYGEN COMPOUNDS
QUANTITATIVE CHEMICAL ANALYSIS
SOILS
TISSUE DISTRIBUTION
TRANSITION ELEMENT COMPOUNDS
URINE
USA
WASTES